| Avengers | Move | WR Garrett Wilson (JET) [To IL], WR Jayden Reed (GB) |
| Sign | RB Kenneth Gainwell (PIT) |
| Deplorables | Sign | WR John Metchie (JET) |
| Move | RB Marshawn Lloyd (GB) [To IL], RB Trey Benson (ARI) |
| BillsMafia | Move | WR Tre Harris (LAC) [1FP] |
| Minutemen | Waive | LB Logan Wilson (DAL) |
| Sign | DL Arik Armstead (JAX) |
| Mayhem | Sign | PK Joey Slye (TEN) [2FP][Extra Pick] |
| Waive | WR Olamide Zaccheaus (CHI) |
| Dragons | Trade to NittanyLions | Week 13 Waiver Pick |
| Waive | TE Jake Tonges (SF) |
| Sign | TE Noah Fant (CIN) |
| Dawgs | Sign | QB Marcus Mariota (WAS) |
| Waive | TE Ja'Tavion Sanders (CAR) |
| NittanyLions | Move | WR Matthew Golden (GB) [To PS] |
| Trade to Dragons | Week 12 Waiver Pick |
| Mayhem | Move | LB Mack Wilson (ARI) [To IL] |
| Sign | WR Andrei Iosivas (CIN) [1FP] |
| Avengers | Move | RB J.K. Dobbins (DEN) [To IR], TE Sam LaPorta (DET) [To IL], TE Brenton Strange (JAX) |
| Deplorables | Waive | DB Quentin Lake (LAR) |
| Bruins | Waive | PK Matt Gay (FA) |
| Sign | PK Harrison Mevis (LAR) |
| Dragons | Sign | LB Quincy Williams (JET) [1FP] |
| Waive | QB Justin Fields (JET), LB Henry To'oTo'o (HOU) |
| Move | QB Tyler Shough (NO) [1FP] |